Crumpler's gender and race made almost everything harder in her life. Her incredible determination led her to help women and civil rights, despite much discrimination. Many felt women were too sensitive, not smart enough, and physically unable to be physicians. She also lived from 1831-1865 (before, during, and after the Civil War) when tensions between races ran high. Prior to Crumpler, these people also made "firsts" in medicine and fought for their rights.
The Emancipation Proclamation went into effect in 1863, freeing all U.S. slaves. Crumpler was already a nurse, accepted and attending college before much of her race was even free.
The Emmancipation Proclamation; Source: The Library of Congress